New Killer Drug Targets Any Virus
- Posted on August 13, 2011 at 11:31am by
Liz Klimas
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Scientists think they’ve developed the ultimate killer. But don’t worry. It’s on your side.
It’s name is DRACO and it could be the next all-inclusive virus killing drug. Scientists at MIT are in the process of developing a drug that identifies and kills cells that have been invaded by a virus, while leaving healthy cells alone.
These microscope images show that DRACO, a virus killing drug developed at MIT, was successful at killing virus-infected cells. (MIT)
Tested against 15 different viruses, the drug proved effective against all of them. First, the drug identifies virus-infected cells by targeting a molecule common in all of them. New Scientist reports:
Nearly every virus generates strings of double-stranded RNA longer than 30 base pairs during transcription and replication, in an attempt to duplicate itself and commandeer its host cell’s machinery. Healthy mammalian cells do not produce double-stranded RNA longer than 23 base pairs.
The body’s own immune system has an enzyme that searches for double-stranded RNA longer than 23 base pairs. When it finds them, it actives the infected cell’s immune response. But some viruses have evolved to outsmart this enzyme.
What Tom Rider and his team at MIT’s Lincoln Laboratory did to catch these viruses was pair the aforementioned enzyme that finds abnormal RNA with a protein that triggers cell death. New Scientist goes on:
The drug “catches the virus with its pants down”, by destroying the cell before new viruses have been assembled inside it, explains Rider. Even if fragmented virus molecules escape the obliterated cell, they will be missing the protein coat that helps them to travel between cells, and so will not infect surrounding healthy tissue. Rider calls his drug double-stranded RNA (dsRNA)-activated caspase oligomeriser (DRACO).
According to an MIT press release, the scientists initially did testing on human and animal cells, but did use the drug in mice infected with H1N1 as well. The drug cured the mice and left them unharmed. The scientists are moving forward with researching its success on other viruses in mice.
Although results look promising, New Scientists include a couple different perspectives that could pose problems for DRACO in the future.
Andrea Branch of the Mount Sinai School of Medicine in New York City thinks the work is intriguing but has some reservations about its practicality. She points out that DRACO is a large protein, which may not enter cells easily.
That said, she agrees that administering DRACO early in an infection could be effective – but adds that destroying all cells infected with the virus can be dangerous in people with advanced viral infections. “Suppose 100 percent of your hepatocytes [liver cells] are infected and you used this – you would die of liver failure.”
Timothy Tellinghuisen of the Scripps Research Institute in Jupiter, Florida, adds that some viruses have evolved ways to conceal their double-stranded RNA, and so could elude DRACO. Still, “this is really an interesting paper, a very clever approach to getting rid of cells containing double-stranded RNA”, he says.
The results of this study are published in Plos One. Rider, the lead scientist for this study is also know for inventing PANACEA, another antivirual therapeutic, and CANARY (Cellular Analysis and Notification of Agtigen Risks and Yields), a sensor for rapid pathogen detection and identification.
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Comments (114)
BSdetector
Posted on August 13, 2011 at 4:29pmWe have to destroy this technology as it is the product of that evil Capitalism which is infecting our country.
Report Post »Don’t worry, ObaMao and his comrades are hard at work figuring out how to quash this uprising of ingenuity and entrepreneurism!
MicahJank
Posted on August 13, 2011 at 4:25pmCan it get rid of all the virus’ in Washington?
Report Post »SFsuper49er
Posted on August 13, 2011 at 9:08pmI wish they could come up with a pill that could cure leftist (liberal) disease. Call it, ”Instant Brain Pill“ or ”Anti-Destruction Pill”
Report Post »jhaydeng
Posted on August 13, 2011 at 9:19pmI’ll pass! Isn’t Draco Harry Potters nemesis?
Report Post »jzs
Posted on August 13, 2011 at 10:17pmMaybe you missed the comment, “The body’s own immune system has an enzyme that searches for double-stranded RNA longer than 23 base pairs. When it finds them, it actives the infected cell’s immune response. But some viruses have evolved to outsmart this enzyme.”
Do you know what word you missed? Read it again. The word is “evolved.” There’s not a word here on this thread questioning “evolution” in this context. Why? Because there’s no connection anyone saw with religion. But the fact is that the concept of evolution is insidiously working it’s way into common thinking. Everyone reads about viruses evolving and accepts it without a thought.
Like the evolution of life, the concept of evolution is surviving as the “fittest” of ideas. You never may never believe it, but your children will. And not them, their children.
Report Post »Pontiac
Posted on August 13, 2011 at 11:57pm“Hey, evolution, we don’t take kindly to your kind around here!”
Report Post »At least from what I’ve seen… Nice someone else is willing to point this stuff out to the irrational dopes on here.
kryptonite
Posted on August 14, 2011 at 10:15amC’mon, JZS, it’s horizontal gene transfer (LGT), not vertical transfer (Darwinian “fittest” idiocy), of which there is no evidence. This transfer ability is the nature of microbes and what characterizes them as such.
Our children will not believe the hogwash, if we teach them the truth. The truth shall set you free.
Report Post »foobear
Posted on August 14, 2011 at 4:55pm@JZS: Evolution of viruses to evade antiviral measures and bacteria becoming resistant to antibiotics is only something a total blockhead could deny has happened.
Are you denying it has happened? What is the source of MRSA then?
Lol.
Report Post »TimAZ
Posted on August 14, 2011 at 8:09pmIf it were a virus in DC maybe. But Liberalism is a mental disorder so no antiviral treatment will help. :)
Report Post »svan71
Posted on August 14, 2011 at 8:25pm@jzs when it evolves into something other than a virus ie lizard into chicken, then we can talk. Until then keep your head squarley up your bum.
Report Post »SpeckChaser
Posted on August 14, 2011 at 11:14pm@jzs
Report Post »Jzs is correct. I decided to evolve 4 more sets of arms because I see the vast improvement it could make in my day to day activities. Not to mention, I will be much more efficient at catching specs. I might disagree with evolution if not for the solid results I’m seeing in my personal life.
Pontiac
Posted on August 15, 2011 at 12:56amAnd dinosaur bones are made of angel dust to keep non-believers from believing…
Report Post »Don‘t you people dare deny the words written by the David Koresh’s and Marshall Applewhites of their day!!!
chazman
Posted on August 15, 2011 at 8:32am… Liberal Marxist‘ aren’t candidates, being as how liberalism is a virus! Ha Ha Ha Ha Ha huh?
Report Post »andredegas
Posted on August 13, 2011 at 3:54pmSuprised with ObamaCare looming that anyone is even experimenting with drugs. Wonder if this would assist in cancer? (Cancer is still thought to be a virus based disease)
Report Post »momsense
Posted on August 13, 2011 at 7:05pmI wish they wold find a cure for cancer—filthy disease.Has taken 2 good friends and 3 members of my family. Maybe this is the start of something wonderful.
Report Post »dheard
Posted on August 13, 2011 at 8:22pmThere are a lot of cancers that are known to be caused by viruses but not all of them. Human papillomavirus being the first that comes to mind, but there are many more. This would be an interesting development but I am cautious about what affects it might have w/ long-term use, or really just use in general. Great bit of engineering though.
Report Post »Pontiac
Posted on August 13, 2011 at 11:49pmmomsense, did your friends have lousy diets?
Report Post »The key may be to starve cancer.
http://www.ted.com/talks/william_li.html
Rusty-nail
Posted on August 13, 2011 at 3:52pmProverbs 8:12…witty inventions
Report Post »skitrees
Posted on August 13, 2011 at 5:44pmOR….maybe….Romans 1:22 “Professing themselves to be wise, they became fools”
Report Post »Bernard
Posted on August 13, 2011 at 3:45pmI always wondered what is common between various viruses to call them a virus, and I believed it that particular gene that is common among all viruses is found then viral diseases would have a cure. Great article.
Report Post »let us prey
Posted on August 13, 2011 at 2:47pmCan it stop the obama drama?
Report Post »lylejk
Posted on August 13, 2011 at 1:07pmEarlier this week, we heard of a possible cure for cancer. Now we have one that looks like it can cure all viruses. Now all that is left is diabetes. Oh yes, they did cure diabetes with direct injections in the pancreas with capsicain (i.e., cayenne pepper), but you don’t ever hear of this anymore. They want people to die folks, so none of these cool ways of healing will ever get implemented otherwise their utopia of population control won’t ever happen. They already got rid of DDT (which kills the misquitos that causes malaria). They gave what most thought was a good excuse but did they really study that well enough? So they tolerate malaria (which kill more then most realize) to keep the population down. Hate to sound paranoid, but may I am a little. Don’t have any hope that these cool novel approaches, especially if they work, will ever get implemented or, it will so only for the control freaks and nothing will go towards the peons like most here are including me. :)
Report Post »Midwest Blonde
Posted on August 13, 2011 at 1:24pmDDT is was also a good solution for Bed Bugs. Currently bed bugs are spreading thru the USA. Hard to get rit of now but with DDT use, they were easy to get rid of.
Gee thanks government, for giving us back PESTS.
Report Post »lylejk
Posted on August 13, 2011 at 1:31pmThey just took away the only tool that prevented them (politicians) from getting into your home Midwest Blonde. lol
:)
Report Post »let us prey
Posted on August 13, 2011 at 3:00pmA bit off topic. Did libs lobby against DDt in Africa due to thin shells on bird eggs? They said nets were better, yet there are millions dying of malaria w/out DDT.
Report Post »I Love Howie Carr
Posted on August 13, 2011 at 5:49pmlet us prey
Report Post »yes bird shells. never even proven to do that harm when used properly. have you seen the commercials with celebrities prancing around with nets and trying to get people to donate so that everyone in africa can walk around with a net on? so hilarious.
VoteBushIn12
Posted on August 13, 2011 at 7:01pmActually lylejk, the reason none of these cures are on the market is all thanks to your love child Capitalism. Here is how it works,
Getting medication approved costs money – a lot of it (like hundreds of millions of dollars lots).
Capsicain, for example, is not a new chemical or substance; it has existed in its present form for many years.
Because it has existed publicly for so long it cannot be patented.
Since no company can claim sole rights to it via patent license they don’t stand to make a lot of money selling it (since competitors have the option of creating the drug also)
If no company picks it up there is no one to pay for the research to get FDA approval and therefore no way it can ever come to market.
You have two options.
1) You remove the FDA and let them sell the drugs without proving they work or guaranteeing safety / liability. Obviously this is not a good idea since the FDA is the only thing making sure the Orange Juice your drink isn’t actually cow pee.
OR
2) Get rid of the greedy capitalistic mindset that is encouraging Big Business to let thousands of people die in the name of their bottom line.
So you see, this has nothing to do with population control. It has to do with Capitalist Greed.
…Did I just make you a socialist?
Report Post »lylejk
Posted on August 13, 2011 at 11:16pmNo; but I agree that pharmaceutical companies have to spend a lot of dough to try to get their drug out. I also agree with you that doctors and pharmaceutical companies rather treat a disease then cure it in order to make more money. I am against greed when that greed affects the livelihood of people and their lives. Still capitalism is moral so long as prudence is considered. People have to bring home the bacon so to speak and that’s the moral thing to do. The problem with pharmaceutical companies and insurance companies is they deal with the devil (the government) way too much. Case in point: Obamacare. That’s my beef with these entities. I still believe (have hope anyway) that people will ultimately do the right thing. But I do put too much faith in my fellow man and maybe that is my problem. :)
Report Post »Robert DeBeaux
Posted on August 14, 2011 at 7:59pmBaldness, I want a cure for baldness.
Report Post »Also, tooth decay, I want a panacea for tooth decay.
how about abscesses? Zits? Snake bite? Rodent bite? Bacterial meningitis?
How are we still alive? OMG Help!!!!
Wait, I know…..
I will kneel down and pray. God will cure me instantly. No matter what I have. If he doesn’t, then I was meant to suffer. Or it was the Devil who outsmarted God. Or, maybe I should have used that free will to take my azz to the doctor and get treated with knowledge that man has worked and suffered for.
Every time someone dies, there is a lesson to be learned that might save someone else from that fate.
Or I can just wait in terrible agony. NOTTTTTTTTTT!
manuelbetten
Posted on August 13, 2011 at 12:56pmWake up people, when the funding gets low write a promising article about the new miracle drug you are working on and then the money will flowing into your department in perpetuity.
Report Post »SoiledDove
Posted on August 13, 2011 at 1:09pmWhich, in turn, makes people’s lives much, much better.
Report Post »koon_cat
Posted on August 13, 2011 at 7:41pmOr…the funding stops and miraculously, we hear about cures! I worked for a scientist based bureau and was always amused that a scientific experiment produced favorable results at precisely the same time the scientist was scheduled for retirement.
Report Post »crackerone
Posted on August 13, 2011 at 12:55pmHope it doesn’t hurt my erections lasting 4 hrs or longer!
Report Post »Stoic one
Posted on August 13, 2011 at 1:32pmAre you insinuating that it is a virus????
Report Post »aaron11
Posted on August 13, 2011 at 5:00pmSpeak for yourself!
Report Post »TulsaYeeHaw
Posted on August 13, 2011 at 10:13pmWouldn‘t that be your wife’s job?
Report Post »gmoneytx
Posted on August 13, 2011 at 12:47pmYes, that’s great but can it cure Obamanation?
Report Post »affinnity
Posted on August 13, 2011 at 12:55pmThe Liberals don’t want to cure that disease.
Report Post »SamIamTwo
Posted on August 13, 2011 at 12:56pmDo we have any volunteers to plunge the needle into Obama?
Report Post »nysparkie
Posted on August 13, 2011 at 12:40pmAhhh, squirt some towards Washington, DC. Please.
Report Post »AMERICA4EVER
Posted on August 13, 2011 at 12:38pmCan’t wait to see how much it costs, or you may never hear of it again.
Report Post »affinnity
Posted on August 13, 2011 at 12:33pmI’m all for it. I say we do human trials on Anti-Christian Atheist Scientists first, followed by Liberals and finally Muslim’s. If they all die we know it doesn’t work and if they live we can use it too.
Report Post »hogtrashhd
Posted on August 13, 2011 at 12:32pmthis is hogwash.. they haven’t come up with a cure for ANYTHING since the polio vaccine.. they figured out it was more lucrative to keep the disease going.. money money money.. they don’t WANT a CURE for ANYTHING….too much money in charities and other crap…
Report Post »olddog
Posted on August 13, 2011 at 12:27pmI hope it can cure liberalism the most deadly virus known!!!
Report Post »affinnity
Posted on August 13, 2011 at 12:36pmI agree.
Report Post »RebelSon
Posted on August 15, 2011 at 12:10pmThere’s no cure for liberalism until the brain transplant becomes a reality. It used to disappear on it‘s own as it’s host matured. However, maturity is now often postponed, sometimes indefinitely by the entitlement mentality. To cure the disease of liberalism, you must first cure the entitlement mentality by refusing to feed it.
Report Post »Drakkhanlord
Posted on August 13, 2011 at 12:13pm“” “Suppose 100 percent of your hepatocytes [liver cells] are infected and you used this – you would die of liver failure.“ ””
Report Post »I can see a lot of good , but also a lot of evil from this…Govt with a bio weapon that if changed just a molecule , could attack the human body and kill billions…
Anyone know of any medication that does not have worse side effects that the illness prescribed for…?
foobear
Posted on August 14, 2011 at 7:18pmThe molecule itself wouldn’t replicate like a bioweapon.
If the government wanted to kill billions, it already has the power to do so. Take your pick of:
Conventional Weaponry
Biological Agents
Chemical Agents
Nuclear Weapons
There – don’t you feel better now?
Report Post »Bobby P
Posted on August 13, 2011 at 12:12pmCan it fix stupid?
Report Post »billjones4
Posted on August 13, 2011 at 12:00pmThis is how the zombies will be created…
Report Post »drattastic
Posted on August 13, 2011 at 12:06pmLOL ,that’s what I was thinking
Report Post »Devil Dog 7175
Posted on August 13, 2011 at 1:50pmBring on the Zombies!!!
Report Post »BillyPenn
Posted on August 13, 2011 at 6:41pmThey are already amongst us. they are called Democrats.
Report Post »marshwillow
Posted on August 13, 2011 at 11:56amWow what a name.I thought that when I read about the dragon it would be literal.But perhaps this is the new biblical dragon….
Report Post »skwerllyGait
Posted on August 13, 2011 at 12:13pmThanx for putting it in that perspective. O_o
Report Post »Jenny Lind
Posted on August 13, 2011 at 11:51amForgive me if I stay a little leary, we now have antibiotic resistent diseases, and I worry we can outsmart ourselves. I think I will wait and see.
Report Post »vennoye
Posted on August 13, 2011 at 12:03pmWhat a smart answer! Have seen too many lawsuits over new drugs to hop on board with new ones, Internist I know will not prescribe any medication less than 10 years old. Thinks it takes that long to see the full side effects on people.
Report Post »HorseCrazy
Posted on August 13, 2011 at 12:25pmVennoy, I am a patient not an md but I have that 10yr rule for my family when we need medical care. glad to see dr’s using this. I recommend to all of my friends and family.
Report Post »Truthbeliever2
Posted on August 13, 2011 at 1:02pmWhat about the people who are dying and want to use this drug as a last ditch effort to save their life. The FDA will not let them near it.
I love the government… No I wish gov’t would keel over and DIE!!!
Report Post »Gonzo
Posted on August 13, 2011 at 11:47amDoes it cure liberalism? Mass produce it and get it out there…QUICK!
Report Post »drattastic
Posted on August 13, 2011 at 12:07pmI’m afraid that may be terminal .
Report Post »quicker
Posted on August 13, 2011 at 12:25pmI would be happy if it cured cranalrectumitis
Report Post »ramburner
Posted on August 13, 2011 at 7:37pm@Quicker; Barney Frank has a cure for that. He used it on camera on MSNBC just the other day!
Report Post »hi
Posted on August 13, 2011 at 11:41amBut some viruses have evolved to outsmart this enzyme.
some viruses have evolved ways to conceal their double-stranded RNA,
The above statements are untrue. One virus of many already had the ability to conceal their double-stranded RNA. It can be passed on. It didn’t accidentally acquire the ability in response.
Report Post »Snowleopard {gallery of cat folks}
Posted on August 13, 2011 at 11:40amInteresting indeed, and if it actually works, then the guarantee is the Obama administration will sure as hades ban its usage here in the nation.
Report Post »Reverend_Child
Posted on August 13, 2011 at 11:50amGallery of Cat Folks…?
Report Post »Link?
Encinon
Posted on August 13, 2011 at 11:37amIf it wasn’t for the republicans we would have had a cure or the common cold centuries ago. They always want to cut taxes which leaves no money for the government to come up with the answers to all of our problems. If not for republicans the world would know no illnesses, everyone would be rich, no one would be hungry and there would be peace everywhere. Why do you baggers hate everyone so much.
Report Post »Reverend_Child
Posted on August 13, 2011 at 11:48amWe were beat up as kids, and no one smote the beat-uppers, so we vowed revenge upon the entire world and will not rest until we’ve doused it with gasoline and set it all alight.
Report Post »Hence our support for the oil industry. Kinda all falls into place from that point, no?
(As with a previous post, I just can‘t be sure whether you’re serious or tongue-in-cheek. Strongly leaning toward the latter. Trusting my response might evoke similar uncertainties. How’d I do?)
GoingBeck
Posted on August 13, 2011 at 11:53amTo be sure. The former utopia of the Soviet Union was flooded with millions of people who wanted to live there. The Chicoms have had to turn away millions of people wanting to live in their utopia too. North Korea…
Report Post »hi
Posted on August 13, 2011 at 11:54amThe private sector , not government, comes up with cures. Everything the government does is bankrupt including the post office, schools, medicare, medicaid, social security and so on. The private sector is always better because there is incentive to achieve. In government there is incentive to sleep in the bathrooms because you get paid even if you don’t produce.
Report Post »joe1234
Posted on August 13, 2011 at 11:55amyeah and if LURCH (john fing kerry, who went to vietnam, cut himself shaving and got a purple heart) would have been president, christopher reeve would have walked…
its so wonderful that obama is president, he’s healed the oceans….too bad his holy hands don’t work on the economy, but thats ok….
Report Post »UlyssesP
Posted on August 13, 2011 at 12:03pmCenturies ago? If not for republicans the world would know no illnesses, everyone would be rich, no one would be hungry and there would be peace everywhere?
The naked ignorance is amazing.
Report Post »MerryColin
Posted on August 13, 2011 at 12:15pmWhat an idiot you are!
Gubmint finds the cure for NOTHING. They gather and report statistics, trace infectious diseases, collect samples, and REPORT on advances developed by PRIVATE researchers, those big bad capitalistic drug companies, and universities. It’s called the CDC and NIH you moron.
Go back in your hole and pray that you will never have to depend on gubmint to help you stay alive in the event you get a dreaded disease. YOU are only worth what you give gubmint. If they were in the business of curing people, if it would cost more to save you than you would give in taxes over your lifetime, you’d be toast! Maybe not such a bad idea for mental defectives like you…
Reverend Child— What are you on? Seriously, am I the only person here who doesn’t get his comments?
Report Post »Gonzo
Posted on August 13, 2011 at 12:19pmI may print that comment and hang it on my wall. Just to teach my kids how idiot liberals think.
Report Post »banjarmon
Posted on August 13, 2011 at 12:29pm@ ENCINON
If it weren’t for the Government , WE WOULD HAVE NO PROBLEMS!
Report Post »jakartaman
Posted on August 13, 2011 at 1:21pmMaybe if it were not for liberalism an aborted baby could have lead to the cure
Report Post »Moron!
Devil Dog 7175
Posted on August 13, 2011 at 1:54pmDropped on his head a time or two, too many me thinks…
Report Post »fatjack
Posted on August 13, 2011 at 3:06pmGet out of the car and I want my ring back. Walk home after a statement like that.
Report Post »RebelSon
Posted on August 15, 2011 at 12:12pmOMG, yes! And there would be rainbows and unicorns everywhere!
Report Post »MODEL82A1
Posted on August 13, 2011 at 11:35amIf God didn’t want there to be horrible, deadly viruses, He wouldn’t have created them @6000′years ago.
Report Post »Chialms
Posted on August 13, 2011 at 11:42amI really hope that was sarcasm. This development, if proven safe by human medical standards, could be huge. I’ll be watching this story.
Report Post »Reverend_Child
Posted on August 13, 2011 at 11:46amLOL Dunno if you’re being serious or tongue-in-cheek. The “horrible, deadly” part suggests the latter, but I’ve occasionally seen similar arguments offered in perfect sincerity.
Report Post »Since most online comment threads seem to mostly just be opinion polls, I’ll go ahead and lodge one to the effect of “I don’t think God minds us monkeying around with the medicinal tools He gave us.” Or if He does, then hey, cool… naughty us.
Betting He gets more annoyed by our constant species-wide willingness to go the opposite route, though, with all the oft-indiscriminate killing and burning and stealing and whatnot. But then, I might be wrong about that one, too. (shrug)
Maybe He’ll spell it out to us someday in person, so clearly that our every last question and doubt will be rinsed away. I think that’d be keen.
MODEL82A1
Posted on August 13, 2011 at 11:55amIf you’re a good Christian, does it matter if I’m being serious? If you’re a good Christian, you have to agree.
Report Post »joe1234
Posted on August 13, 2011 at 11:56amGod obviously wanted stupid though…
Report Post »hi
Posted on August 13, 2011 at 11:58amGod’s creation was perfect. He created free will. When adam sinned by eating the fruit, death and suffering started.
God always had a plan for redemption, Jesus Christ. We will have no pain and suffering when Christ comes again for those who ask Him into their hearts.
Report Post »Reverend_Child
Posted on August 13, 2011 at 12:48pm> If you’re a good Christian, does it matter if I’m being serious? If you’re a good Christian, you have to agree.
Hardly. I’m a perfectly good Christian who never, ever does anything wrong, ‘coz if I were to sin (as the Bible promises I will, again and again in life), it would automatically negate my Christianity and make me a hypocrite in the eyes of anyone with an axe to grind against Christianity. Especially if their axe is bigger than their capacity to deal in philosophical fairness, which is strangely nearly always the case. (shrug) Humans, right?
Anyway, having established myself as a perfectly pure and pettable Christian whose poop never, ever stinks, I now exercise my right and ability to disagree!
Except for the one problem that I kinda actually *do* agree. Yes, viruses and whatnot do indeed exist within the boundaries of God’s will, if only ‘coz *everything* that exists does so by His sufferance. Q.E.D.
Everything, to include the tools to fight illness. Which brings us to the question of your point.
Report Post »crackerone
Posted on August 13, 2011 at 12:51pmIt will cure that too!
Report Post »AlansTigg
Posted on August 13, 2011 at 3:04pmthat was my reaction too
Report Post »