"Never ever read the comments [on Twitter]," co-host Sunny Hostin advises at the beginning of the clip.
"I always read the comments. Who doesn't read the comments?" Milano countered.
"Do you turn the comments off?" she asked co-host Joy Behar.
"No," Behar answered. "I just don't read them. I'm not interested unless it's somebody that I respect."
"I left [Twitter]," co-host Whoopi Goldberg chimed in.
"Listen, I've spent many, many days with my therapist talking about Twitter and social media," Milano said.
"Because of what some anonymous person said to you?" Hostin asked.
"Yeah, it's hurtful," Milano answered.
"Somebody who doesn't know you, hasn't met you, doesn't know your family, doesn't know you, doesn't know anything about you?" Goldberg asked.
"Yeah," Milano repeated, seemingly missing the point.
"Yes, there are mean anonymous people out there," Dave said in response to the clip. "It's just the nature of all of this, and before social media, people used to ... write mean things about people in the bathroom stall ... people do mean things."
Dave likened Twitter and other social media platforms to an "old school" town square where people would congregate and share ideas.
"Let's go back 100 years, right, little towns all over America," he said. "Then in the town square, that's where people would congregate. That's where everybody would go for commerce, to get food, etc. And then they'd start talking and exchanging ideas. And there might have even been a guy on a soapbox and he'd be complaining about this or that, but you did not have to talk to everybody. You did not have to turn to everybody who commented on something, and if there was a crazy person over there, you might just walk the other way."
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