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Feds Revoke Approval of Life-Prolonging Treatment for Breast Cancer, Insurers Could Bail on Patients


A "chillingly blunt assertion of regulatory power against a drug for breast cancer."

For those unfamiliar, Avastin is a targeted therapy drug used in conjunction with chemotherapy in the treatment of certain advanced cancers -- primarily colorectal, kidney, and lung, but also breast cancer. The drug works by restricting the blood supply to tumors. The goal is to starve tumors of the precious blood needed to grow, thus shrinking them. While the drug carries with it serious side effects, it has been proven successful in suppressing tumor growth in various types of cancers.

Now, however, the FDA is revoking its approval of Avastin in the treatment of advanced breast cancer only. This means that doctors can still prescribe the drug to breast cancer patients as they deem fit, but insurers now might not cover the exorbitant cost. A year's supply of Avastin can cost roughly $100,000.

For people with certain types of advanced cancers for which there is no cure, Avastin is sometimes the last-line of defense in suppressing tumor growth and preventing the cancer from metastasizing for a prolonged period of time, improving prognosis.

Now, breast cancer patients who have been receiving the drug with good results are faced with a very difficult challenge ahead, especially if their insurers decide not to cover the cost of treatment. The Wall Street Journal notes the "chillingly blunt assertion of regulatory power against a drug for breast cancer." In this instance, the power of a federal agency is outweighing doctors and their patients -- the ones who have the most to lose:

The extraordinary Avastin saga has become a kind of randomized controlled trial, pitting the Food and Drug Administration's power against potentially life-saving drugs for terminally ill patients. The results are proving that the former is far stronger, with FDA Commissioner Margaret Hamburg's decision yesterday to withdraw the biologic medicine as a treatment option for women with metastatic breast cancer.

The details of the FDA's decision are outlined in the following Associated Press report:

WASHINGTON (The Blaze/AP) -- The government delivered a blow to some desperate patients Friday as it ruled the blockbuster drug Avastin should no longer be used to treat advanced breast cancer.

Avastin is hailed for treating colon cancer and certain other malignancies. But the Food and Drug Administration said it appeared to be a false hope for breast cancer: Studies haven't found that it helps those patients live longer or brings enough other benefit to outweigh its dangerous side effects.

"I did not come to this decision lightly," said the FDA's commissioner, Dr. Margaret Hamburg. But she said, "Sometimes despite the hopes of investigators, patients, industry and even the FDA itself, the results of rigorous testing can be disappointing."

Avastin remains on the market to treat certain colon, lung, kidney and brain cancers. Doctors are free to prescribe any marketed drug as they see fit. So even though the FDA formally revoked Avastin's approval as a breast cancer treatment, women could still receive it - but their insurers may not pay for it. Some insurers already have quit in anticipation of FDA's long-expected ruling.

However, "Medicare will continue to cover Avastin," said Brian Cook, spokesman for the Centers for Medicare & Medicaid Services. The agency "will monitor the issue and evaluate coverage options as a result of action by the FDA but has no immediate plans to change coverage policies."

Including infusion fees, a year's treatment with Avastin can reach $100,000.

The ruling disappointed patients who believe Avastin is helping to curb their incurable cancer.

"It's saved my life," said a tearful Sue Boyce, 54, of Chicago. She's taken Avastin in addition to chemotherapy since joining a research study in 2003. Her breast cancer eventually spread to her lungs, liver and brain, but Boyce says she is stable and faring well.

"So I'm hoping the insurance company will grandfather me in to continue taking it," she said.

The Avastin saga began in 2008, when an initial study suggested the drug could delay tumor growth for a few months in women whose breast cancer had spread to other parts of the body. Over the objection of its own advisers and to the surprise of cancer groups, FDA gave Avastin conditional approval - it could be sold for such women while manufacturer Genentech tried to prove it really worked.

The problem: Ultimately, the tumor effect was even smaller than first thought. Across repeated studies, Avastin patients didn't live longer or have a higher quality of life. Yet the drug causes some life-threatening risks, including severe high blood pressure, massive bleeding, heart attack or heart failure and tears in the stomach and intestines, the FDA concluded. In two public hearings - one last year and one this summer - FDA advisers urged the agency to revoke that approval.

"The science is clear: Breast cancer patients are more likely to be harmed than helped by Avastin," said Diana Zuckerman of the National Research Center for Women and Families in Washington.

Genentech had argued the drug should remain available while it conducted more research to see if certain subsets of breast cancer patients might benefit, and some patients and their doctors had argued passionately for the drug.

"There certainly are patients who benefit tremendously," said Boyce's oncologist, Dr. Melody Cobleigh of Rush University Medical Center. "We'll just be battling with the insurance companies."

"For those not fortunate enough to be on Medicare or an insurance plan that covers it, it's a death sentence," Christi Turnage of Madison, Miss., said of the FDA's decision. Her breast cancer had moved into her lungs before she began Avastin three years ago and the spreading stopped, but Turnage said her insurer is ending coverage and she will seek financial help from Genentech's access program.

Hamburg said that she considered those arguments but that scientifically there are no clues yet to identify who those rare Avastin responders would be - putting a lot of people at risk in order for a few to get some as-yet-unknowable benefit. She urged Genentech to do that research, saying the FDA "absolutely" would reconsider if the company could find the right evidence.

Genentech, part of Swiss drugmaker Roche Group, pledged to begin that research.

"We are disappointed with the outcome," said company chief medical officer Dr. Hal Barron. "We remain committed to the many women with this incurable disease and will continue to provide help through our patient support programs to those who may be facing obstacles to receiving their treatment in the United States."

The breast cancer organization Susan G. Komen for the Cure said that it respected the FDA's decision and that it was time for researchers to concentrate on finding so-called biomarkers that would tell which drug is right for which patient.

"Each type of cancer is very different from another in important ways, and in the end it's no surprise that Avastin's effectiveness may not be equivalent against all types of cancer," said Dr. Neal Meropol of University Hospitals Case Medical Center in Cleveland, who has long used Avastin for colon cancer.

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