CHICAGO (AP) -- Comedy actor, director and writer Harold Ramis, best known for his roles in movies such as "Ghostbusters" and "Stripes," died Monday at his suburban Chicago home after a four-year battle with an autoimmune disease, his talent agency said.
Ramis, 69, died early Monday morning of complications from vasculitis, which causes inflammation and damage to blood vessels, said Chris Day, a spokesman at United Talent Agency. Ramis was surrounded by family and friends.
Ramis was a key factor in some of the biggest blockbuster comedies in the 1970s and 1980s.
FILE - In this Dec. 12, 2009 file photo, actor and director Harold Ramis walks the Red Carpet as he arrives to celebrate The Second City's 50th anniversary in Chicago. An attorney for Ramis said the actor died Monday morning, Feb. 24, 2014, from complications of autoimmune inflammatory disease. He was 69. Ramis is best known for his roles in the comedies "Ghostbusters" and "Stripes." (AP Photo/Jim Prisching)
He co-wrote "Animal House," which starred fellow Second City alum John Belushi. He teamed up with Second City alums Bill Murray and Dan Aykroyd on "Ghostbusters," in which Ramis co-starred and helped write.
He also co-wrote and directed "Groundhog Day" and "Caddyshack," and co-wrote "Meatballs" - all of which starred Murray.
"The best comedy touches something that's timeless and universal in people," Ramis told The Associated Press in a 2009 story about the 50th anniversary of Second City. "When you hit it right, those things last."
FILE - In an undated file photo, Bill Murray, Dan Aykroyd, center, and Harold Ramis, right, appear in a scene from the 1984 movie "Ghostbusters". Harold Ramis died early Monday, Feb. 24, 2014, in Chicago from complications of autoimmune inflammatory disease, according Fred Toczek , an attorney for Ramis. He was 69. (AP Photo, File)
More recently, he directed "Analyze This," starring Billy Crystal and Robert DeNiro.
Aykroyd issued a statement Monday, saying he was "deeply saddened to hear of the passing of my brilliant, gifted, funny friend ... May he now get the answers he was always seeking."
Ramis was born Nov. 21, 1944 in Chicago. He is survived by his wife, Erica Ramis; sons Julian and Daniel; daughter, Violet, and two grandchildren.