Joe Biden's Major Gaffe at the Expense of San Francisco 49ers Fans

Vice President Joe Biden took the handoff and headed for the end zone.

Blockers in front of him, plenty of daylight, and—speaking in the friendly confines of not-so-conservative San Francisco—the VP even had the political home-field advantage.

Then Biden, just inches from paydirt, threw in a last-second juke for style points, shouting out that “the Giants are on their way to the Super Bowl.”

Fumble!

Oh no. Say it ain't so, Joe.

Biden's latest gaffe came during a speech yesterday in San Francisco's financial district for President Barack Obama’s reelection bid. But even Biden's staunchest political allies took it personally when he lauded the name of the squad their beloved 49ers will battle this Sunday for the NFC Championship.

And the Niner fans let Joe have it.

When his verbal misstep drew boos from the crowd, Biden issued a fast mea culpa, noting he's used to talking about the San Francisco Giants’ baseball victories. (The Giants won the 2010 World Series and visited the White House last July to celebrate the victory.) Then Biden clarified that he meant to say “49ers” when referring to the team that was "on their way to the Super Bowl."

Biden was in the Bay Area with his wife for several campaign stops. The couple was scheduled to meet with several tech leaders yesterday evening, including the heads of Apple, Google, Yahoo, Netflix and Zynga. He is scheduled to head for Reno and Los Angeles today.

Enjoy a collection of the VP's infamous goofs here: