Lopez, during an interview with Candace Owens in June, said it is "dangerous" for parents to make a determination about whether their child is a boy or a girl based on how that child feels at the age of 3.
When the comments got more attention over the past week, Lopez apologized for what he said, calling his previous remarks "ignorant and insensitive."
"Mario buckled to the mob," said radio host Charlamagne tha God on "The Breakfast Club." "Mario Lopez said nothing wrong. We're talking about a 3-year-old child. What logical decision can a child make at 3? You should not make that determination at 3. Let the kid grow up."
Mario Lopez Clarifies 'Dangerous' Transgender Comments youtu.be
Comedian D.L. Hughley said he felt Lopez was right in what he said at first.
"I'm w/ @MarioLopezExtra if you're 3-yrs-old your ass ain't making the rules in my house," Hughley wrote on Twitter. "Until your ass is responsible 4 yourself, paying bills, you can't even sign a permission slip for a field trip, then my rules. U don't get to choose UR gender at 3."
Kristy Swanson, who was the star of "Buffy the Vampire Slayer," said she was disappointed that Lopez decided to apologize.
"I have to say to @MarioLopezExtra I am sad to hear you apologized for doing nothing wrong," Swanson tweeted. "Like a good smart pal of mine says... 'Never bend a knee to the rage mob. Ever.'"
Joe Rogan discussed the issue on an episode of his podcast, "The Joe Rogan Experience," with comedian Brian Moses.
"This is what people are deeply concerned about," Rogan said, "is authoritarian reinforcement of their particular way of thinking and behaving. And it's because people have the opportunity to complain now. If you didn't like the way someone addressed women or something, you really didn't have a way to broadcast it 20 years ago. But now anybody can just get on Twitter or Facebook and it can go viral and a bunch of other f***ing pink-haired weirdos will retweet you, and next thing you know there's a goddamn mob after Mario Lopez."
Joe Rogan on Mario Lopez's Transgender Child Comments youtu.be