The report cites two sources who are familiar with the off-the-record dinner Madeleine Westerhout had with members of the media.
Westerhout told reporters that she had a better relationship with the president than he had with his daughters Ivanka and Tiffany Trump.
She also told them that the president did not like being in photographs with his daughter Tiffany Trump because he perceived her as being overweight.
The off-the-record meeting with reporters happened in New Jersey as the president was vacationing.
"She had a couple drinks and in an uncharacteristically unguarded moment, she opened up to the reporters," said one of the sources to Politico.
They added that Westerhout joked that the president couldn't pick Tiffany out of a crowd.
When the president was asked about the report on Friday, he told reporters that Westerhout was a "very good person" and it was too bad that she was leaving. "I wished her well," he added.
He also said that he would call his daughter Tiffany Trump via phone when he arrived at Camp David for the weekend, but denied that he had ever disparaged her in any way.
"I love Tiffany," he said.
Here's the latest on the Westerhout resignation:
Trump's personal assistant abruptly exits administration www.youtube.com