On Friday, Alaskans learned her decision: She's in. And, this time, she said: "The gloves are off."
Murkowski faces tough odds with her write-in candidacy. She has lost support from members within the Republican establishment, who are backing the Republican nominee, Joe Miller. She also has just more than six weeks to gear up a campaign, motivate her staff and turn out the vote.
But she told supporters — who greeted her at an Anchorage convention center with chants of "Run, Lisa, Run!" — that she couldn't walk away and ignore the pleas of Alaskans who urged her to offer them a choice between the "extremist" views of Miller, a self-described constitutional conservative and tea party favorite, and the "inexperience" of Democrat Scott McAdams, a small-town mayor.
"So I am here to tell you, you are disenfranchised no more," she said.
Republican leaders — including Republican National Committee chairman Michael Steele, Sens. John Cornyn and Mitch McConnell — reiterated their support for Miller.
McConnell, the Senate Republican leader, said he had told Murkowski that if she ran as a write-in, she no longer had his support for any leadership roles. Murkowski resigned her position as vice chairwoman of the Senate Republican conference, her campaign spokesman confirmed.
"Lisa has served her state and our party with distinction," McConnell said in a statement, "but Republicans acknowledge the decision Alaskans made and join them in support of the Republican nominee, Joe Miller, the next senator for Alaska."
Former Alaska Gov. Sarah Palin, who endorsed Miller and through her PAC gave $5,000 to his campaign, urged Murkowski recognize the results of the primary.
"Listen to the people, respect their will," Palin said via Twitter. "Voters chose Joe instead."
Miller said Murkowski's re-entry won't change his strategy, which includes calling for reining in government spending and giving Alaska greater control over its resource base.
Miller told The Associated Press Friday night that voters chose to support him because they wanted to move away from Murkowski's agenda.
"Liberals don't relinquish power easily, that would be my first observation," he said.
Murkowski acknowledged making mistakes during the primary but promised to be more aggressive this time.
During the primary, she touted the benefits of her seniority for Alaska and ran largely on her record. Miller, meanwhile, cast Murkowski as part of the problem in a big-spending, out-of-control Washington. And the California-based Tea Party Express, which reported spending more than $550,000 in support of Miller, labeled her a liberal Republican and repeatedly claimed she opposed repeal of the federal health care overhaul — claims she called false but didn't challenge until late in the race.
The group said it would work twice as hard as it did during the primary to beat her if she stayed in the race.
Murkowski has some advantages: she enjoys widespread name recognition and her campaign estimates she has about $1 million in the bank. Plus, the race features a "kind of perfect storm of the things you need for a write-in to be successful," pollster Ivan Moore said. Among those, he said: a vast middle of Alaskans looking between Miller and McAdams and questioning their choices.
The largest bloc of registered voters in Alaska are nonpartisan and undeclared. Miller beat Murkowski in the party primary by just over 2,000 votes.
"I've been saying from the beginning she can win this thing," Moore said. "So people have got to write the name. So what? It's not rocket science."
The convention center where the rally took place had a table where people could sign up to help Murkowski's campaign. Signs declaring "Let's Make History" abounded. There was also literature on how to cast a write-in vote.
Lt. Gov. Craig Campbell, who oversees elections in Alaska, has asked the attorney general to review what would be necessary for a write-in vote for Murkowski to count. His understanding of the law is that voters would have to mark the ballot oval and write in either the candidate's last name or the name as it appears on the candidate's declaration to run. But he wants an opinion on that, and on how far elections officials need to go in enforcing spelling.
Murkowski, who got off a plane from Washington not long before the rally, took aim at Republicans, pundits and others who'd labeled a run a "futile effort."
"Well, perhaps it's time they met one Republican woman who won't quit on Alaska," she said, taking a swipe at Palin, who resigned last year in the middle of her first term as governor.
Heather Handyside, a spokeswoman for McAdams, said the Democratic candidate welcomed Murkowski to the race. She said the campaign didn't see how it was "statistically possible" for Murkowski to win and that her entry doesn't change McAdams' strategy at all.
"He still respects Sen. Murkowski but he knows it's impossible for her to win," she said.Rove responds to write-in bid on FNS: 'Sad but Sorry': Associated Press writer Mary Pemberton contributed to this report from Anchorage, Alaska.